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After 12–18hours centrilobular hepatic necrosis occurs whichmay be accompanied by renal tubular necrosisand hypoglycaemia that may progress to coma.Jaundice starts after 2 days.

Patients develop ahyponatremic hypochloremic, hyperkalemic metabolic acidosis that is associated withwater loss and dehydration.

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In: Haddad GG, Farber JP (eds) Developmentalneurobiology of breathing, vol 53, Lung biology inhealth and disease series. A retrospective study of surgical treatment of chronic radiation enteritis.